For research use only. Not for therapeutic Use.
CIM0216 (Cat No.: I011229) is a potent small-molecule agonist of transient receptor potential (TRP) channels, particularly TRPM3 and TRPV1, which are involved in nociception, thermosensation, and inflammatory signaling. By activating these ion channels, CIM0216 promotes calcium influx, making it a valuable tool for studying pain mechanisms, sensory neuron function, and TRP-mediated signaling pathways. Researchers use CIM0216 to investigate neuronal excitability, inflammatory pain models, and potential therapeutic targets. Although not developed for clinical application, it remains an important probe in neurobiology and pain research.
| CAS Number | 1031496-06-6 |
| Synonyms | 2-(3,4-dihydro-2H-quinolin-1-yl)-N-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide |
| Molecular Formula | C21H21N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H21N3O2/c1-15-14-19(23-26-15)22-21(25)20(17-9-3-2-4-10-17)24-13-7-11-16-8-5-6-12-18(16)24/h2-6,8-10,12,14,20H,7,11,13H2,1H3,(H,22,23,25) |
| InChIKey | KSEXDSJYVSEVGF-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NO1)NC(=O)C(C2=CC=CC=C2)N3CCCC4=CC=CC=C43 |
| Reference | [1]. Katharina Held, et al. Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1363-72. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
