For research use only. Not for therapeutic Use.
Chroman 1 dihydrochloride（Cat No.:I045070）is a potent and selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK), particularly ROCK1 and ROCK2 isoforms. These kinases regulate cytoskeletal dynamics, cell shape, motility, and proliferation. By inhibiting ROCK activity, Chroman 1 dihydrochloride modulates actin filament organization and reduces cellular contractility, making it valuable in studies of cell migration, cancer metastasis, and neuroregeneration. The dihydrochloride salt enhances solubility and formulation stability for laboratory use. Chroman 1 is also used to improve the survival and maintenance of human pluripotent stem cells in culture conditions.
| Synonyms | (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide;dihydrochloride |
| Molecular Formula | C24H30Cl2N4O4 |
| Purity | ≥95% |
| IUPAC Name | (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide;dihydrochloride |
| InChI | InChI=1S/C24H28N4O4.2ClH/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18;;/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29);2*1H/t18-;;/m0../s1 |
| InChIKey | BZROBPNUVVJVJQ-NTEVMMBTSA-N |
| SMILES | CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)[C@H]3CC4=C(C=CC(=C4)OC)OC3.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
