Cholesterol 24-hydroxylase-IN-1

• CAT Number: I044053
• CAS Number: 1613480-70-8
• Molecular Formula: C17H23N5O
• Molecular Weight: 313.40
• Purity: ≥95%
• Synonyms: N,N-dimethyl-1-[4-(4-methylpyrazol-1-yl)pyridin-3-yl]piperidine-4-carboxamide
• InChI: InChI=1S/C17H23N5O/c1-13-10-19-22(12-13)15-4-7-18-11-16(15)21-8-5-14(6-9-21)17(23)20(2)3/h4,7,10-12,14H,5-6,8-9H2,1-3H3
• InChIKey: MYSVNUHQXQZBQE-UHFFFAOYSA-N
• SMILES: CC1=CN(N=C1)C2=C(C=NC=C2)N3CCC(CC3)C(=O)N(C)C

Cholesterol 24-Hydroxylase-IN-1（Cat No.:I044053）is a selective inhibitor of cholesterol 24-hydroxylase (CYP46A1), an enzyme that converts cholesterol into 24S-hydroxycholesterol, a key step in cholesterol turnover in the brain. By blocking CYP46A1 activity, this compound reduces 24S-hydroxycholesterol production, affecting cholesterol homeostasis and neuronal signaling. It is especially valuable in neuroscience research, including studies on Alzheimer’s disease, epilepsy, and neurodegeneration. Cholesterol 24-Hydroxylase-IN-1 supports investigation into the therapeutic potential of modulating brain cholesterol metabolism and offers a targeted approach to exploring the role of CYP46A1 in cognitive and neuroinflammatory disorders.