Chloroacetamido-PEG4-C2-Boc

• CAT Number: I016992
• CAS Number: 1365655-90-8
• Molecular Formula: C17H32ClNO7
• Molecular Weight: 397.89
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[2-[2-[(2-chloroacetyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C17H32ClNO7/c1-17(2,3)26-16(21)4-6-22-8-10-24-12-13-25-11-9-23-7-5-19-15(20)14-18/h4-14H2,1-3H3,(H,19,20)
• InChIKey: VCADUZGDEHVWCF-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCNC(=O)CCl

Chloroacetamido-PEG4-C2-Boc(CAT: I016992) is a heterobifunctional polyethylene glycol (PEG) linker featuring a chloroacetamide group for selective alkylation of thiols and a Boc-protected amine for orthogonal conjugation. The four-unit PEG spacer with a C2 extension enhances solubility, flexibility, and hydrophilicity, while minimizing steric hindrance in coupling reactions. The chloroacetamide moiety enables efficient thiol-specific modification, making this reagent particularly valuable for cysteine labeling, protein conjugation, and drug delivery applications. The Boc-protected amine provides controlled deprotection for further functionalization, expanding versatility. Chloroacetamido-PEG4-C2-Boc is an ideal building block for bioconjugation, PROTAC synthesis, and advanced materials research requiring dual, orthogonal reactivity.