Chloro-N,N,N’,N’-tetramethyl-formamidinium Hexafluorophosphate

• CAT Number: R007337
• CAS Number: 94790-35-9
• Molecular Formula: C5H12ClF6N2P
• Molecular Weight: 280.579
• Purity: ≥95%
• Synonyms: N-[Chloro(dimethylamino)methylene]-N-methyl-methanaminium Hexafluorophosphate; Tetramethylchloroformamidinium Hexafluorophosphate; TCFH
• Storage: -20°C
• IUPAC Name: [chloro(dimethylamino)methylidene]-dimethylazanium;hexafluorophosphate
• InChI: InChI=1S/C5H12ClN2.F6P/c1-7(2)5(6)8(3)4;1-7(2,3,4,5)6/h1-4H3;/q+1;-1
• InChIKey: CUKNPSDEURGZCO-UHFFFAOYSA-N
• SMILES: CN(C)C(=[N+](C)C)Cl.F[P-](F)(F)(F)(F)F

Chloro-N,N,N’,N’-tetramethyl-formamidinium hexafluorophosphate (Cat No.: R007337) is a versatile chlorinating and activating reagent used in organic synthesis. It is particularly effective in peptide and nucleoside chemistry for activating carboxylic acids and promoting amide or ester bond formation. The reagent features a reactive formamidinium chloride core stabilized by the hexafluorophosphate counterion, offering high reactivity with minimal side reactions. TMU-Cl·PF₆ is valued for its ability to facilitate efficient coupling reactions under mild conditions, enhancing yields in complex molecule synthesis.