Chlormezanone

• CAT Number: I013876
• CAS Number: 80-77-3
• Molecular Formula: C₁₁H₁₂ClNO₃S
• Molecular Weight: 273.74
• Purity: ≥95%
• Target: Others
• Solubility: 10 mM in DMSO
• IUPAC Name: 2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
• InChI: InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3
• InChIKey: WEQAYVWKMWHEJO-UHFFFAOYSA-N
• SMILES: CN1C(S(=O)(=O)CCC1=O)C2=CC=C(C=C2)Cl

Chlormezanone, a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
Target: Others
Chlormezanone 200 mg had a relaxing effect which became apparent as a shortened reaction time at 30 min. Chlormezanone 400 mg did not affect psychomotor performance, nor did it enhance the effects of alcohol on psychomotor skills [1]. The metabolism of chlormezanone has been studied in rats, dogs, and man. After oral administration to the rat, the tissue : plasma concentration ratios are very close to unity, and the mean decrease in concentrations between 2 and 4 hr postmedication is about 30 per cent. In the dog, an oral dose of 7 mg/kg gives a peak plasma level of 5-6 μg/ml, while 200 mg/kg gives a peak level of 140-160 μg/ml. The plasma half-lives for these doses [2].

Reference

[1]. Linnoila, M., Effects of antihistamines, chlormezanone and alcohol on psychomotor skills related to driving. European Journal of Clinical Pharmacology, 1973. 5(4): p. 247-254.[2]. McChesney, E.W., et al., Metabolism of chlormezanone in man and laboratory animals. Biochem Pharmacol, 1967. 16(5): p. 813-26.