Chemotactic Domain of Elastin

• CAT Number: I040405
• CAS Number: 92899-39-3
• Molecular Formula: C22H38N6O7
• Molecular Weight: 498.57
• Purity: ≥95%
• Synonyms: 2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
• InChI: InChI=1S/C22H38N6O7/c1-11(2)17(23)20(33)24-9-15(29)27-18(12(3)4)21(34)26-13(5)22(35)28-8-6-7-14(28)19(32)25-10-16(30)31/h11-14,17-18H,6-10,23H2,1-5H3,(H,24,33)(H,25,32)(H,26,34)(H,27,29)(H,30,31)/t13-,14-,17-,18-/m0/s1
• InChIKey: RLCSROTYKMPBDL-USJZOSNVSA-N
• SMILES: CC(C)C(C(=O)NCC(=O)NC(C(C)C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NCC(=O)O)N

Chemotactic Domain of Elastin(CAT: I040405), often referred to as elastokine VGVAPG or elastin-derived peptide (EDP), is a bioactive sequence released during elastin degradation. It exhibits potent chemotactic activity by binding to the elastin-binding protein (EBP) on various cell types, including fibroblasts, monocytes, and endothelial cells. This domain plays a critical role in tissue remodeling, inflammation, and tumor progression, influencing cell migration, proliferation, and angiogenesis. Due to its signaling properties, it is widely used in dermatological, cardiovascular, and oncology research. Supplied at high purity, the Chemotactic Domain of Elastin is ideal for studying extracellular matrix dynamics and cell-matrix interactions.