Chembridge-5861528

• CAT Number: I003200
• CAS Number: 332117-28-9
• Molecular Formula: C19H23N5O3
• Molecular Weight: 369.43
• Purity: ≥95%
• Synonyms: (R)-N-(4-(sec-butyl)phenyl)-2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetamide
• Target: Neuronal Signaling
• Solubility: DMSO ＜ 9 mg/mL
• Storage: Store at RT
• IUPAC Name: N-(4-butan-2-ylphenyl)-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide
• InChI: InChI=1S/C19H23N5O3/c1-5-12(2)13-6-8-14(9-7-13)21-15(25)10-24-11-20-17-16(24)18(26)23(4)19(27)22(17)3/h6-9,11-12H,5,10H2,1-4H3,(H,21,25)
• InChIKey: ZUTUWJYMCADJHD-UHFFFAOYSA-N
• SMILES: CCC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C

Chembridge-5861528 (Cat No.: I003200) is a small-molecule compound sourced from the ChemBridge chemical library, commonly used in high-throughput screening and drug discovery research. While its precise biological target may vary depending on the screening context, it typically features a drug-like structure suitable for lead optimization. Chembridge-5861528 is studied for its potential modulatory effects on cellular pathways, making it a useful tool in identifying novel therapeutic candidates. Its structural diversity and bioactivity profile support its role in early-stage medicinal chemistry and pharmacological research efforts.

Reference

[1]. Wei H, et al. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54.
[2]. Wei H, et al. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 2010 Mar;58(3):578-84.
[3]. Wei H, et al. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010 Aug 2;479(3):253-6.