For research use only. Not for therapeutic Use.
CHD1Li 6.11（Cat No.:I044062）is a selective small-molecule inhibitor of chromodomain-helicase-DNA-binding protein 1 (CHD1), a chromatin remodeler involved in transcriptional regulation, nucleosome positioning, and DNA repair. By targeting CHD1’s ATPase activity, CHD1Li 6.11 impairs its chromatin remodeling function, leading to altered gene expression and disruption of transcriptional homeostasis. This compound is particularly valuable in prostate cancer research, where CHD1 loss or dysregulation plays a critical role in tumorigenesis and therapy resistance. CHD1Li 6.11 supports studies on epigenetic regulation, chromatin dynamics, and potential vulnerabilities in cancers dependent on chromatin remodeling pathways.
| CAS Number | 2716890-91-2 |
| Synonyms | 2-(4-bromothiophen-2-yl)-N-[4-[(6-methyl-2-pyrrolidin-1-ylpyrimidin-4-yl)amino]phenyl]acetamide |
| Molecular Formula | C21H22BrN5OS |
| Purity | ≥95% |
| IUPAC Name | 2-(4-bromothiophen-2-yl)-N-[4-[(6-methyl-2-pyrrolidin-1-ylpyrimidin-4-yl)amino]phenyl]acetamide |
| InChI | InChI=1S/C21H22BrN5OS/c1-14-10-19(26-21(23-14)27-8-2-3-9-27)24-16-4-6-17(7-5-16)25-20(28)12-18-11-15(22)13-29-18/h4-7,10-11,13H,2-3,8-9,12H2,1H3,(H,25,28)(H,23,24,26) |
| InChIKey | ACDZBXZERLBYOW-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NC(=N1)N2CCCC2)NC3=CC=C(C=C3)NC(=O)CC4=CC(=CS4)Br |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
