Chamaejasmenin B

• CAT Number: R005515
• CAS Number: 89595-71-1
• Molecular Formula: C32H26O10
• Molecular Weight: 570.54
• Purity: ≥95%
• Synonyms: (2S,3S)-3-[(2S,3S)-5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-methoxyphenyl)-2,3-dihydrochromen-4-one
• InChI: InChI=1S/C32H26O10/c1-39-19-7-3-15(4-8-19)31-27(29(37)25-21(35)11-17(33)13-23(25)41-31)28-30(38)26-22(36)12-18(34)14-24(26)42-32(28)16-5-9-20(40-2)10-6-16/h3-14,27-28,31-36H,1-2H3/t27-,28-,31-,32-/m1/s1
• InChIKey: BTCICADMSGBCKA-QWWQXMGCSA-N
• SMILES: COC1=CC=C(C=C1)C2C(C(=O)C3=C(C=C(C=C3O2)O)O)C4C(OC5=CC(=CC(=C5C4=O)O)O)C6=CC=C(C=C6)OC

Chamaejasmenin B (Cat No.: R005515) is a naturally occurring flavonoid compound isolated from plants of the Stellera or Daphne genus. It exhibits diverse bioactivities, including anti-inflammatory, anti-cancer, and anti-microbial effects. Chamaejasmenin B has been shown to inhibit tumor cell proliferation and induce apoptosis through modulation of key signaling pathways such as NF-κB and MAPK. It is used in pharmacological research to explore its therapeutic potential in oncology and inflammatory diseases. Its plant-derived origin also makes it of interest in natural product drug discovery.

Reference

[1]. Li Q, et al. Chamaejasmenin B, a novel candidate, inhibits breast tumor metastasis by rebalancing TGF-beta paradox. Oncotarget. 2016 Jul 26;7(30):48180-48192.
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[2]. Li Q, et al. Chamaejasmenin B, an Inhibitor for Metastatic Outgrowth, Reversed M2-Dominant Macrophage Polarization in Breast Tumor Microenvironment. Front Immunol. 2021 Dec 28;12:774230.
[Content Brief]