For research use only. Not for therapeutic Use.
CGP78850 (Cat No.: I045488) is a potent, selective inhibitor of the sodium–calcium exchanger (NCX), a membrane transporter critical for regulating intracellular calcium homeostasis in excitable cells such as cardiomyocytes and neurons. By blocking NCX activity, CGP78850 alters calcium influx and efflux, affecting excitation–contraction coupling in the heart and calcium-dependent signaling in the nervous system. It is primarily used in cardiovascular and neurophysiological research to study calcium dynamics, ischemia–reperfusion injury, arrhythmias, and neuroprotection, providing valuable insights into calcium-mediated physiological and pathological processes.
| CAS Number | 258326-83-9 |
| Synonyms | [4-[(2S)-2-acetamido-3-[[1-[[(2S)-4-amino-1-[3-(2-hydroxynaphthalen-1-yl)propylamino]-1,4-dioxobutan-2-yl]carbamoyl]cyclohexyl]amino]-3-oxopropyl]phenyl]methylphosphonic acid |
| Molecular Formula | C36H46N5O9P |
| Purity | ≥95% |
| InChI | InChI=1S/C36H46N5O9P/c1-23(42)39-29(20-24-11-13-25(14-12-24)22-51(48,49)50)34(46)41-36(17-5-2-6-18-36)35(47)40-30(21-32(37)44)33(45)38-19-7-10-28-27-9-4-3-8-26(27)15-16-31(28)43/h3-4,8-9,11-16,29-30,43H,2,5-7,10,17-22H2,1H3,(H2,37,44)(H,38,45)(H,39,42)(H,40,47)(H,41,46)(H2,48,49,50)/t29-,30-/m0/s1 |
| InChIKey | DXUDLEHAROCUHM-KYJUHHDHSA-N |
| SMILES | CC(=O)NC(CC1=CC=C(C=C1)CP(=O)(O)O)C(=O)NC2(CCCCC2)C(=O)NC(CC(=O)N)C(=O)NCCCC3=C(C=CC4=CC=CC=C43)O |
| Reference | [1]. Gay B, et al. Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer. 1999;83(2):235-241. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
