For research use only. Not for therapeutic Use.
CGP52411 (CAT: M092234) is a potent, selective, orally active, and ATP-competitive EGFR inhibitor with an IC₅₀ of 0.3 μM. It blocks pathological Ca²⁺ influx in neuronal cells and significantly inhibits β-amyloid (Aβ42) fibril aggregation, making it of interest in Alzheimer’s disease research. In vitro, CGP52411 suppresses EGFR autophosphorylation and c-Src activity in a dose-dependent manner, while also reducing p185^c-erbB2 tyrosine phosphorylation. Additionally, it inhibits conventional PKC isozymes (α, β-1, β-2, γ) but not nonconventional or atypical isoforms. In vivo, oral administration demonstrates antitumor activity in xenograft models, highlighting its dual utility in oncology and neurodegeneration research.
| CAS Number | 145915-58-8 |
| Synonyms | 5,6-dianilinoisoindole-1,3-dione |
| Molecular Formula | C20H15N3O2 |
| Purity | ≥95% |
| IUPAC Name | 5,6-dianilinoisoindole-1,3-dione |
| InChI | InChI=1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25) |
| InChIKey | AAALVYBICLMAMA-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)NC2=C(C=C3C(=C2)C(=O)NC3=O)NC4=CC=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
