For research use only. Not for therapeutic Use.
CGP 20712 A (CAT: M005017) is a highly selective β₁-adrenoceptor antagonist with an IC₅₀ of 0.7 nM and approximately 10,000-fold selectivity over β₂-adrenoceptors. This exceptional specificity makes it a valuable pharmacological probe for dissecting β₁-mediated signaling. In cardiac myocytes, CGP 20712 A effectively abolishes adenylate cyclase activation via β₂-adrenoceptors, confirming its selective antagonism of β₁ receptors. In vivo studies demonstrate that pretreatment with 5 mg/kg does not alter plasma ACTH responses, supporting its receptor-focused mode of action. CGP 20712 A is widely employed in cardiovascular and receptor pharmacology research to investigate β-adrenergic signaling and therapeutic targeting.
CAS Number | 105737-62-0 |
Synonyms | 2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide;methanesulfonic acid |
Molecular Formula | C24H29F3N4O8S |
Purity | ≥95% |
IUPAC Name | 2-hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenoxy]propyl]amino]ethoxy]benzamide;methanesulfonic acid |
InChI | InChI=1S/C23H25F3N4O5.CH4O3S/c1-30-12-20(23(24,25)26)29-22(30)14-2-4-16(5-3-14)35-13-15(31)11-28-8-9-34-17-6-7-19(32)18(10-17)21(27)33;1-5(2,3)4/h2-7,10,12,15,28,31-32H,8-9,11,13H2,1H3,(H2,27,33);1H3,(H,2,3,4) |
InChIKey | VFPOVCXWKBYDNF-UHFFFAOYSA-N |
SMILES | CN1C=C(N=C1C2=CC=C(C=C2)OCC(CNCCOC3=CC(=C(C=C3)O)C(=O)N)O)C(F)(F)F.CS(=O)(=O)O |
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