For research use only. Not for therapeutic Use.
CFTR Corrector 6（Cat No.:I044689）is a small-molecule compound designed to restore proper folding, trafficking, and function of mutant cystic fibrosis transmembrane conductance regulator (CFTR) proteins, particularly the common F508del mutation found in cystic fibrosis (CF) patients. By stabilizing misfolded CFTR and promoting its transport to the cell surface, CFTR Corrector 6 helps restore chloride ion transport across epithelial membranes. It is primarily used in preclinical research to evaluate CFTR modulation strategies, often in combination with CFTR potentiators. CFTR Corrector 6 contributes to the development of targeted therapies for CF and other CFTR-related disorders.
| CAS Number | 2226970-01-8 |
| Synonyms | 4-amino-7-[[1-(2-fluorophenyl)pyrazol-4-yl]methyl]-5-[2-(trifluoromethyl)pyrimidin-5-yl]pyrrolo[2,3-d]pyrimidine-6-carbonitrile |
| Molecular Formula | C22H13F4N9 |
| Purity | ≥95% |
| IUPAC Name | 4-amino-7-[[1-(2-fluorophenyl)pyrazol-4-yl]methyl]-5-[2-(trifluoromethyl)pyrimidin-5-yl]pyrrolo[2,3-d]pyrimidine-6-carbonitrile |
| InChI | InChI=1S/C22H13F4N9/c23-14-3-1-2-4-15(14)35-10-12(6-33-35)9-34-16(5-27)17(18-19(28)31-11-32-20(18)34)13-7-29-21(30-8-13)22(24,25)26/h1-4,6-8,10-11H,9H2,(H2,28,31,32) |
| InChIKey | LSTMAJPRFFZYIT-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)N2C=C(C=N2)CN3C(=C(C4=C(N=CN=C43)N)C5=CN=C(N=C5)C(F)(F)F)C#N)F |
| Reference | [1]. Joseph Walter Strohbach, et al. Pyrrolopyrimidines as cftr potentiators. WO2018094137A1 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
