Cetraxate hydrochloride

• CAT Number: R003818
• CAS Number: 27724-96-5
• Molecular Formula: C17H24ClNO4
• Molecular Weight: 341.83
• Purity: ≥95%
• Synonyms: 3-[4-[4-(aminomethyl)cyclohexanecarbonyl]oxyphenyl]propanoic acid;hydrochloride
• InChI: InChI=1S/C17H23NO4.ClH/c18-11-13-1-6-14(7-2-13)17(21)22-15-8-3-12(4-9-15)5-10-16(19)20;/h3-4,8-9,13-14H,1-2,5-7,10-11,18H2,(H,19,20);1H
• InChIKey: USROQQUKEBHOFF-UHFFFAOYSA-N
• SMILES: C1CC(CCC1CN)C(=O)OC2=CC=C(C=C2)CCC(=O)O.Cl

Cetraxate hydrochloride (Cat No.: R003818) is an orally active mucosal protective agent widely used in gastrointestinal research. It enhances mucosal defense by stimulating prostaglandin synthesis, promoting mucus secretion, and improving blood flow, thereby aiding in the prevention and healing of gastric and duodenal ulcers. Beyond its gastroprotective effects, cetraxate hydrochloride has demonstrated anti-inflammatory and cytoprotective activities, making it a valuable tool in studying ulcer pathology, oxidative stress, and gastrointestinal pharmacology. Researchers employ it to explore therapeutic strategies for gastric injury and mucosal disorders.

Reference

[1]. Fumihiko Katagiri, et al. Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma. J Pharm Pharmacol. 2004 Apr;56(4):557-61.
[Content Brief]

[2]. H Sumi, et al. Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006). Experientia. 1980 Sep 15;36(9):1103-4.
[Content Brief]