Cetirizine- CAS 83881-51-0

Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.
IC50 value:
Target: Histamine H1 receptor
Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. From Wikipedia.

Catalog Number: I005021

CAS Number: 83881-51-0

PubChem Substance ID:355040246

Molecular Formula: C21H25ClN2O3

Molecular Weight:388.89

Purity: ≥95%

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* For research use only. Not for human or veterinary use.


Synonyms2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid


Molecular Formula: C21H25ClN2O3
Molecular Weight388.89
Target:Histamine Receptor
Solubility10 mM in DMSO ; water:1000 mg/ml
StorageStore at -20°C