Cetirizine- CAS 83881-51-0
Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.
IC50 value:
Target: Histamine H1 receptor
Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. From Wikipedia.
Catalog Number: I005021
CAS Number: 83881-51-0
PubChem Substance ID:355040246
Molecular Formula: C21H25ClN2O3
Molecular Weight:388.89
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid |
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Property
Molecular Formula: | C21H25ClN2O3 |
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Molecular Weight | 388.89 |
Target: | Histamine Receptor |
Solubility | 10 mM in DMSO ; water:1000 mg/ml |
Purity | ≥95% |
Storage | Store at -20°C |