For research use only. Not for therapeutic Use.
Cereblon inhibitor 1（Cat No.:I044074）is a selective small-molecule inhibitor targeting cereblon (CRBN), a substrate receptor of the CRL4^CRBN E3 ubiquitin ligase complex. Unlike cereblon modulators (e.g., lenalidomide), which promote targeted protein degradation, Cereblon inhibitor 1 blocks CRBN function, preventing the ubiquitination and degradation of neo-substrates. This compound is valuable for studying cereblon-dependent protein homeostasis, drug resistance mechanisms, and the biology of immunomodulatory drugs (IMiDs). Cereblon inhibitor 1 serves as a research tool in oncology, neurobiology, and protein degradation to explore therapeutic modulation of ubiquitin-proteasome system pathways.
| CAS Number | 2672489-14-2 |
| Synonyms | 2-chloro-4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-3-fluorophenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile |
| Molecular Formula | C32H28ClF2N5O4 |
| Purity | ≥95% |
| IUPAC Name | 2-chloro-4-[4-[[4-[[2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-3H-isoindol-4-yl]oxymethyl]-3-fluorophenyl]methyl]piperazin-1-yl]-3-fluorobenzonitrile |
| InChI | InChI=1S/C32H28ClF2N5O4/c33-29-20(15-36)6-7-25(30(29)35)39-12-10-38(11-13-39)16-19-4-5-21(24(34)14-19)18-44-27-3-1-2-22-23(27)17-40(32(22)43)26-8-9-28(41)37-31(26)42/h1-7,14,26H,8-13,16-18H2,(H,37,41,42)/t26-/m0/s1 |
| InChIKey | PVJLGFCYPTZLAE-SANMLTNESA-N |
| SMILES | C1CC(=O)NC(=O)[C@H]1N2CC3=C(C2=O)C=CC=C3OCC4=C(C=C(C=C4)CN5CCN(CC5)C6=C(C(=C(C=C6)C#N)Cl)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
