Centhaquin

• CAT Number: I005935
• CAS Number: 57961-90-7
• Molecular Formula: C22H25N3
• Molecular Weight: 331.45
• Purity: ≥95%
• Synonyms: 2-[2-[4-(3-methylphenyl)piperazin-1-yl]ethyl]quinoline
• InChI: InChI=1S/C22H25N3/c1-18-5-4-7-21(17-18)25-15-13-24(14-16-25)12-11-20-10-9-19-6-2-3-8-22(19)23-20/h2-10,17H,11-16H2,1H3
• InChIKey: UJNWGFBJUHIJKK-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC=C1)N2CCN(CC2)CCC3=NC4=CC=CC=C4C=C3

Centhaquine (CAT: I005935) is a novel resuscitative agent under investigation for the treatment of hemorrhagic shock and circulatory collapse. Acting via central and peripheral mechanisms, Centhaquine augments cardiac output while reducing systemic vascular resistance in preclinical hemorrhagic models. Intravenous and intraduodenal administration produces dose-dependent reductions in blood pressure and heart rate in both anesthetized and decerebrate cats. Direct application to the medulla or vertebral artery injections induce hypotension, bradycardia, and reduced vasomotor excitability. Additionally, low-dose intravenous Centhaquine (0.015 mg/kg) improves macro- and microcirculation during CPR, attenuating catecholamine-induced damage. This compound is a promising candidate for critical care and cardiovascular research.