For research use only. Not for therapeutic Use.
Cedirogant (Cat No.:I024304) is an oral, selective inverse agonist of the retinoic acid–related orphan receptor gamma t (RORγt), a key transcription factor regulating Th17 cell differentiation and IL-17 production. By targeting RORγt, cedirogant aims to suppress pathogenic Th17-mediated inflammation implicated in autoimmune diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. It offers a novel mechanism to modulate immune responses without broad immunosuppression. Cedirogant is under clinical investigation and holds promise as a targeted therapy for Th17-driven inflammatory disorders.
| CAS Number | 2055496-11-0 |
| Synonyms | 2-[1-[2,4-dichloro-3-[[7-chloro-5-(trifluoromethyl)indol-1-yl]methyl]benzoyl]piperidin-4-yl]acetic acid |
| Molecular Formula | C24H20Cl3F3N2O3 |
| Purity | ≥95% |
| IUPAC Name | 2-[1-[2,4-dichloro-3-[[7-chloro-5-(trifluoromethyl)indol-1-yl]methyl]benzoyl]piperidin-4-yl]acetic acid |
| InChI | InChI=1S/C24H20Cl3F3N2O3/c25-18-2-1-16(23(35)31-6-3-13(4-7-31)9-20(33)34)21(27)17(18)12-32-8-5-14-10-15(24(28,29)30)11-19(26)22(14)32/h1-2,5,8,10-11,13H,3-4,6-7,9,12H2,(H,33,34) |
| InChIKey | MNEOHCYSHVKLIC-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1CC(=O)O)C(=O)C2=C(C(=C(C=C2)Cl)CN3C=CC4=CC(=CC(=C43)Cl)C(F)(F)F)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
