CDK9-IN-30

• CAT Number: I040622
• CAS Number: 748146-89-6
• Molecular Formula: C16H20FNO3
• Molecular Weight: 293.33
• Purity: ≥95%
• Synonyms: 2-[1-[2-(4-fluoroanilino)-2-oxoethyl]cyclohexyl]acetic acid
• InChI: InChI=1S/C16H20FNO3/c17-12-4-6-13(7-5-12)18-14(19)10-16(11-15(20)21)8-2-1-3-9-16/h4-7H,1-3,8-11H2,(H,18,19)(H,20,21)
• InChIKey: NWYDUMKUVBYKQI-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)(CC(=O)NC2=CC=C(C=C2)F)CC(=O)O

CDK9-IN-30(CAT: I040622) is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation via phosphorylation of RNA polymerase II. By targeting CDK9, this compound disrupts the transcription of anti-apoptotic and oncogenic genes, making it highly valuable in cancer research, particularly in hematologic malignancies and solid tumors. CDK9-IN-30 demonstrates strong activity in suppressing tumor cell proliferation and promoting apoptosis, with minimal off-target effects on other CDKs. It is a powerful tool for studying transcriptional regulation, cell cycle progression, and therapeutic targeting of transcriptional addiction in cancer.