For research use only. Not for therapeutic Use.
CDK9-IN-13（Cat No.:I044094）is a potent and selective inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcriptional elongation through phosphorylation of the RNA polymerase II C-terminal domain. By blocking CDK9 activity, this compound suppresses transcription of short-lived anti-apoptotic proteins like MCL-1, making it highly effective in inducing apoptosis in cancer cells, particularly hematologic malignancies. CDK9-IN-13 is widely used in oncology research to study transcriptional control, drug resistance, and targeted therapy development. It is a valuable tool for evaluating CDK9 as a therapeutic target in aggressive and transcriptionally addicted tumors.
| CAS Number | 2768712-71-4 |
| Synonyms | 5-[2-[1-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-propan-2-ylpyridin-2-one |
| Molecular Formula | C27H35N5O2 |
| Purity | ≥95% |
| IUPAC Name | 5-[2-[1-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-propan-2-ylpyridin-2-one |
| InChI | InChI=1S/C27H35N5O2/c1-19(2)32-17-21(6-7-25(32)33)22-8-11-28-27-23(22)16-24(29-27)20-9-14-30(15-10-20)18-26(34)31-12-4-3-5-13-31/h6-8,11,16-17,19-20H,3-5,9-10,12-15,18H2,1-2H3,(H,28,29) |
| InChIKey | GLYHKPNATCXTDU-UHFFFAOYSA-N |
| SMILES | CC(C)N1C=C(C=CC1=O)C2=C3C=C(NC3=NC=C2)C4CCN(CC4)CC(=O)N5CCCCC5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
