For research use only. Not for therapeutic Use.
CDK2-IN-3 (Cat No.: R021935) is a selective small molecule inhibitor of Cyclin-Dependent Kinase 2 (CDK2), an essential enzyme regulating the cell cycle transition from G1 to S phase. By inhibiting CDK2 activity, CDK2-IN-3 disrupts DNA replication and induces cell cycle arrest, promoting apoptosis in proliferative cells. It is widely used in cancer research to study CDK2-dependent signaling, assess potential drug resistance pathways, and explore therapeutic interventions in tumors with deregulated cell cycle control. CDK2-IN-3 is a valuable tool for preclinical drug discovery.
| CAS Number | 222035-13-4 |
| Synonyms | 4-[(5-bromo-2-hydroxy-1H-indol-3-yl)diazenyl]benzenesulfonamide |
| Molecular Formula | C14H11BrN4O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C14H11BrN4O3S/c15-8-1-6-12-11(7-8)13(14(20)17-12)19-18-9-2-4-10(5-3-9)23(16,21)22/h1-7,17,20H,(H2,16,21,22) |
| InChIKey | IWDDMLCHUYBHHD-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1N=NC2=C(NC3=C2C=C(C=C3)Br)O)S(=O)(=O)N |
| Reference | [1]. S T Davis, et al. Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science. 2001 Jan 5;291(5501):134-7. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
