CDK12-IN-2

• CAT Number: I045607
• CAS Number: 2244987-03-7
• Molecular Formula: C32H32N6O2
• Molecular Weight: 532.64
• Purity: ≥95%
• Synonyms: 3-benzyl-1-[4-[(5-cyanopyridin-2-yl)amino]cyclohexyl]-1-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]urea
• InChI: InChI=1S/C32H32N6O2/c1-37-22-26(10-18-31(37)39)25-8-13-28(14-9-25)38(32(40)35-20-23-5-3-2-4-6-23)29-15-11-27(12-16-29)36-30-17-7-24(19-33)21-34-30/h2-10,13-14,17-18,21-22,27,29H,11-12,15-16,20H2,1H3,(H,34,36)(H,35,40)
• InChIKey: HDJBGURZVALLMD-UHFFFAOYSA-N
• SMILES: CN1C=C(C=CC1=O)C2=CC=C(C=C2)N(C3CCC(CC3)NC4=NC=C(C=C4)C#N)C(=O)NCC5=CC=CC=C5

CDK12-IN-2 (Cat No.: I045607) is a selective small-molecule inhibitor of cyclin-dependent kinase 12 (CDK12), a transcription-associated kinase that regulates RNA polymerase II activity and expression of DNA damage response genes. By blocking CDK12, CDK12-IN-2 impairs homologous recombination repair, leading to genomic instability and increased sensitivity to DNA-damaging agents and PARP inhibitors. It is widely used in cancer research to study transcriptional regulation, DNA repair pathways, and synthetic lethality approaches. CDK12-IN-2 provides a valuable probe for oncology and therapeutic target validation studies.

Reference

[1]. Masahiro Ito, et al. Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7710-7728.
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