For research use only. Not for therapeutic Use.
Cdk1/2 Inhibitor III(CAT: R032979) is a selective small-molecule inhibitor of CDK1/2 kinases, with an IC₅₀ of 2.1 μM for CDK1/cyclin B. While it exhibits only modest cellular antiproliferative potency, this compound is a valuable tool for dissecting cell cycle regulation, particularly the roles of CDK1 and CDK2 in G1/S and G2/M transitions. Its weak cellular activity makes it suitable for use in mechanistic studies where partial inhibition is desired without broad cytotoxic effects. Cdk1/2 Inhibitor III is frequently applied in cancer biology, checkpoint regulation, and drug discovery research focused on CDK signaling pathways.
| CAS Number | 443798-55-8 |
| Synonyms | 3-amino-N-(2,6-difluorophenyl)-5-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide |
| Molecular Formula | C15H13F2N7O2S2 |
| Purity | ≥95% |
| IUPAC Name | 3-amino-N-(2,6-difluorophenyl)-5-(4-sulfamoylanilino)-1,2,4-triazole-1-carbothioamide |
| InChI | InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-14(22-13(18)23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23) |
| InChIKey | UPNMPXFYMWBVBA-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)F)NC(=S)N2C(=NC(=N2)N)NC3=CC=C(C=C3)S(=O)(=O)N)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
