CD73-IN-4

• CAT Number: I045429
• CAS Number: 2216764-29-1
• Molecular Formula: C16H23ClN5O7P
• Molecular Weight: 463.81
• Purity: ≥95%
• Synonyms: [(2R,3S,4R,5R)-5-[6-chloro-4-(cyclopentylamino)pyrazolo[3,4-d]pyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxymethylphosphonic acid
• InChI: InChI=1S/C16H23ClN5O7P/c17-16-20-13(19-8-3-1-2-4-8)9-5-18-22(14(9)21-16)15-12(24)11(23)10(29-15)6-28-7-30(25,26)27/h5,8,10-12,15,23-24H,1-4,6-7H2,(H,19,20,21)(H2,25,26,27)/t10-,11-,12-,15-/m1/s1
• InChIKey: IVHVIBKVJIZKOC-RTWAVKEYSA-N
• SMILES: C1CCC(C1)NC2=C3C=NN(C3=NC(=N2)Cl)C4C(C(C(O4)COCP(=O)(O)O)O)O

CD73-IN-4 (Cat No.: I045429) is a potent, selective small-molecule inhibitor of ecto-5′-nucleotidase (CD73), an enzyme that converts extracellular AMP to adenosine, thereby modulating immune responses and tumor microenvironment signaling. By blocking CD73 activity, CD73-IN-4 reduces adenosine production, enhancing anti-tumor immunity and potentially improving responses to immunotherapies. It is used in cancer research to study adenosine-mediated immunosuppression and its role in tumor progression, metastasis, and immune evasion. CD73-IN-4 is a valuable tool for exploring novel therapeutic strategies targeting purinergic signaling in oncology and immunology.

Reference

[1]. Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5.
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