For research use only. Not for therapeutic Use.
CD532 (Cat No.: I024273) is a potent and selective inhibitor of anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase involved in oncogenic signaling in cancers such as non-small cell lung cancer and anaplastic large-cell lymphoma. CD532 uniquely stabilizes ALK in an inactive conformation, effectively blocking kinase activation and overcoming resistance to first-generation ALK inhibitors. It is widely used as a chemical probe to study ALK-driven oncogenesis, drug resistance mechanisms, and targeted therapeutic development, providing valuable insights into precision oncology research and kinase biology.
| CAS Number | 1639009-81-6 |
| Synonyms | 1-[4-[[4-[(5-cyclopentyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-3-[3-(trifluoromethyl)phenyl]urea |
| Molecular Formula | C26H25F3N8O |
| Purity | ≥95% |
| InChI | InChI=1S/C26H25F3N8O/c27-26(28,29)17-6-3-7-20(14-17)33-25(38)32-19-10-8-18(9-11-19)31-24-30-13-12-22(35-24)34-23-15-21(36-37-23)16-4-1-2-5-16/h3,6-16H,1-2,4-5H2,(H2,32,33,38)(H3,30,31,34,35,36,37) |
| InChIKey | GBMIFBVLJSCVJT-UHFFFAOYSA-N |
| SMILES | C1CCC(C1)C2=CC(=NN2)NC3=NC(=NC=C3)NC4=CC=C(C=C4)NC(=O)NC5=CC=CC(=C5)C(F)(F)F |
| Reference | [1]. Gustafson WC, et, al. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 8;26(3):414-427. [2]. Lee JK, et, al. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11;29(4):536-547. |
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