For research use only. Not for therapeutic Use.
CCT245232（Cat No.:I044037）is a potent and selective inhibitor of checkpoint kinase 1 (CHK1), a key regulator of DNA damage response and cell cycle control. By blocking CHK1 activity, CCT245232 disrupts cell cycle arrest and DNA repair mechanisms, thereby enhancing the cytotoxic effects of DNA-damaging agents such as chemotherapy and radiation. This makes it particularly valuable in cancer research, especially in tumors with high replication stress or p53 deficiencies. CCT245232 supports studies aimed at overcoming therapeutic resistance and exploring synthetic lethality strategies by targeting cell cycle checkpoints in oncogenic contexts.
| CAS Number | 1693731-14-4 |
| Synonyms | N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-methylquinoline-6-carboxamide |
| Molecular Formula | C27H23N3O4 |
| Purity | ≥95% |
| IUPAC Name | N-[5-(2,3-dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-methylquinoline-6-carboxamide |
| InChI | InChI=1S/C27H23N3O4/c1-16-3-8-21(29-26(31)20-7-10-24-25(14-20)34-12-11-33-24)15-23(16)30-27(32)19-6-9-22-18(13-19)5-4-17(2)28-22/h3-10,13-15H,11-12H2,1-2H3,(H,29,31)(H,30,32) |
| InChIKey | RZQWMJAOUJLEAM-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC3=C(C=C2)OCCO3)NC(=O)C4=CC5=C(C=C4)N=C(C=C5)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
