CCT129957

• CAT Number: I004834
• CAS Number: 883098-58-6
• Molecular Formula: C17H15N3O3
• Molecular Weight: 309.32
• Purity: ≥95%
• Synonyms: 7-nitro-N-(2-phenylethyl)-1H-indole-2-carboxamide
• InChI: InChI=1S/C17H15N3O3/c21-17(18-10-9-12-5-2-1-3-6-12)14-11-13-7-4-8-15(20(22)23)16(13)19-14/h1-8,11,19H,9-10H2,(H,18,21)
• InChIKey: VXDJRTJBOJFUOC-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CCNC(=O)C2=CC3=C(N2)C(=CC=C3)[N+](=O)[O-]

CCT129957(CAT: I004834) is an indole-based small-molecule inhibitor of phospholipase C-γ (PLC-γ), with an IC₅₀ of ~3 μM and a GC₅₀ of 15 μM. It suppresses Ca²⁺ release in squamous carcinoma cells at ~15 μM, highlighting its role in modulating calcium-dependent signaling. Structural studies suggest that CCT129957 forms a robust hydrogen-bonding network and engages in lipophilic contacts within the PLC-γ binding pocket. Functionally, it demonstrates significant anticancer potential, inhibiting cell growth by ~60–70% in renal UO-31 and breast T-47D cancer lines. CCT129957 is a valuable research tool in cancer biology and signal transduction studies targeting PLC-γ pathways.