CCT128930 hydrochloride

• CAT Number: I045361
• CAS Number: 2453324-32-6
• Molecular Formula: C18H21Cl2N5
• Molecular Weight: 378.30
• Purity: ≥95%
• Synonyms: 4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine;hydrochloride
• InChI: InChI=1S/C18H20ClN5.ClH/c19-14-3-1-13(2-4-14)11-18(20)6-9-24(10-7-18)17-15-5-8-21-16(15)22-12-23-17;/h1-5,8,12H,6-7,9-11,20H2,(H,21,22,23);1H
• InChIKey: OFLOSUNRPFWODP-UHFFFAOYSA-N
• SMILES: C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4.Cl

CCT128930 hydrochloride (Cat No.: I045361) is a potent, selective small-molecule inhibitor of AKT, a serine/threonine kinase involved in the PI3K/AKT/mTOR signaling pathway that regulates cell growth, survival, and metabolism. By targeting all three AKT isoforms, CCT128930 disrupts aberrant signaling commonly seen in cancer, leading to reduced tumor cell proliferation and enhanced apoptosis. The hydrochloride salt form improves its solubility and formulation properties. CCT128930 hydrochloride is primarily used in preclinical research to investigate AKT-driven oncogenic processes and evaluate targeted cancer therapy strategies.

Reference

[1]. Yap TA et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71.
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[2]. Wang FZ, et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 2014;103:118-125.
[Content Brief]