CCR4-351 hydrochloride

• CAT Number: I045464
• CAS Number: 2174938-71-5
• Molecular Formula: C24H28Cl3N7O
• Purity: ≥95%

CCR4-351 hydrochloride (Cat No.: I045464) is a small-molecule antagonist of CC chemokine receptor 4 (CCR4), a G protein–coupled receptor involved in immune cell trafficking, particularly regulatory T cell (Treg) migration. By blocking CCR4, it inhibits Treg recruitment to tumor sites or inflamed tissues, potentially enhancing anti-tumor immunity and modulating inflammatory responses. The hydrochloride salt improves solubility and stability for experimental use. CCR4-351 hydrochloride is employed in immunology and oncology research to study chemokine signaling and develop therapeutic strategies targeting immune suppression and cancer progression.

Reference

[1]. Omar Robles, et al. Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as Single Agent and in Combination with Checkpoint Inhibitors. J Med Chem. 2020 Jul 15.
[Content Brief]