For research use only. Not for therapeutic Use.
CCG-50014（Cat No.:I005892）is a small-molecule inhibitor of regulator of G-protein signaling (RGS) proteins, particularly RGS4. By covalently modifying cysteine residues, it blocks RGS-mediated GTPase-accelerating activity, thereby prolonging G-protein signaling. This action enhances receptor-mediated pathways, making it a valuable research tool for dissecting G-protein–coupled receptor (GPCR) regulation. CCG-50014 has been widely applied in neuroscience and cardiovascular studies to explore its effects on synaptic transmission, neuronal excitability, and cardiac function. Its mechanism helps reveal therapeutic potential of RGS inhibition in neurological, cardiovascular, and metabolic disorders.
| CAS Number | 883050-24-6 |
| Synonyms | 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione |
| Molecular Formula | C16H13FN2O2S |
| Purity | ≥95% |
| IUPAC Name | 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione |
| InChI | InChI=1S/C16H13FN2O2S/c1-11-2-8-14(9-3-11)19-15(20)18(16(21)22-19)10-12-4-6-13(17)7-5-12/h2-9H,10H2,1H3 |
| InChIKey | QUIIIYITNGOFEI-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)N2C(=O)N(C(=O)S2)CC3=CC=C(C=C3)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
