For research use only. Not for therapeutic Use.
CCG-222740（Cat No.:I017965）is a potent small-molecule inhibitor of the Rho/MRTF/SRF transcriptional pathway, a key regulator of cytoskeletal dynamics, fibrosis, and cancer progression. By selectively disrupting MRTF-SRF–mediated gene expression, CCG-222740 suppresses fibrotic signaling and tumor cell invasiveness without broadly affecting general transcription. It has shown strong efficacy in preclinical models of fibrosis and metastatic cancer, highlighting its therapeutic potential. This compound provides researchers with a powerful tool to study cytoskeletal signaling, transcriptional regulation, fibrosis mechanisms, and oncogenic processes linked to aberrant Rho pathway activation.
| CAS Number | 1922098-69-8 |
| Synonyms | N-(4-chlorophenyl)-5,5-difluoro-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide |
| Molecular Formula | C23H19ClF2N2O3 |
| Purity | ≥95% |
| IUPAC Name | N-(4-chlorophenyl)-5,5-difluoro-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide |
| InChI | InChI=1S/C23H19ClF2N2O3/c24-18-6-8-19(9-7-18)27-21(29)17-12-23(25,26)14-28(13-17)22(30)16-4-1-3-15(11-16)20-5-2-10-31-20/h1-11,17H,12-14H2,(H,27,29) |
| InChIKey | PMTPYUTZAJWGPE-UHFFFAOYSA-N |
| SMILES | C1C(CN(CC1(F)F)C(=O)C2=CC=CC(=C2)C3=CC=CO3)C(=O)NC4=CC=C(C=C4)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
