CC-90005

• CAT Number: I024232
• CAS Number: 1799574-70-1
• Molecular Formula: C21H27F2N7O2
• Molecular Weight: 447.48
• Purity: ≥95%
• Synonyms: 2-[[4-(2,2-difluoropropoxy)pyrimidin-5-yl]methylamino]-4-[[(1R,4S)-4-hydroxy-3,3-dimethylcyclohexyl]amino]pyrimidine-5-carbonitrile
• InChI: InChI=1S/C21H27F2N7O2/c1-20(2)6-15(4-5-16(20)31)29-17-13(7-24)9-26-19(30-17)27-10-14-8-25-12-28-18(14)32-11-21(3,22)23/h8-9,12,15-16,31H,4-6,10-11H2,1-3H3,(H2,26,27,29,30)/t15-,16+/m1/s1
• InChIKey: FMKGJQHNYMWDFJ-CVEARBPZSA-N
• SMILES: CC1(CC(CCC1O)NC2=NC(=NC=C2C#N)NCC3=CN=CN=C3OCC(C)(F)F)C

CC-90005 (Cat No.: I024232) is an investigational small-molecule inhibitor of IRAK4 (interleukin-1 receptor-associated kinase 4), a key kinase in toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways that drive inflammation and immune activation. By targeting IRAK4, CC-90005 aims to suppress aberrant inflammatory responses implicated in autoimmune and inflammatory diseases, as well as certain hematologic malignancies like myelodysplastic syndromes. It is currently being evaluated in preclinical and early clinical studies as a potential immunomodulatory therapy with applications in both oncology and chronic inflammatory conditions.

Reference

[1]. Papa P, et, al. Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005. J Med Chem. 2021 Aug 26;64(16):11886-11903.
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