CC-90001

• CAT Number: I024231
• CAS Number: 1403859-14-2
• Molecular Formula: C16H27N5O2
• Molecular Weight: 321.42
• Purity: ≥95%
• Synonyms: 2-(tert-butylamino)-4-[[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino]pyrimidine-5-carboxamide
• InChI: InChI=1S/C16H27N5O2/c1-9-5-6-10(7-12(9)22)19-14-11(13(17)23)8-18-15(20-14)21-16(2,3)4/h8-10,12,22H,5-7H2,1-4H3,(H2,17,23)(H2,18,19,20,21)/t9-,10-,12-/m1/s1
• InChIKey: QBBRJRLJWXRSHQ-CKYFFXLPSA-N
• SMILES: C[C@@H]1CC[C@H](C[C@H]1O)NC2=NC(=NC=C2C(=O)N)NC(C)(C)C

CC-90001（Cat No.:I024231）is a potent, selective, and orally bioavailable inhibitor of c-Jun N-terminal kinase 1 (JNK1), with additional activity against JNK2. It exhibits nanomolar potency (IC₅₀ ≈ 11 nM for JNK1) and effectively blocks downstream phosphorylation events involved in inflammation and fibrosis. CC-90001 has demonstrated anti-fibrotic efficacy in preclinical models and is being clinically evaluated for idiopathic pulmonary fibrosis (IPF) and other fibrotic diseases. Its oral administration leads to significant reductions in fibrotic markers such as collagen and α-SMA. It represents a promising therapeutic candidate in chronic inflammation and fibrotic disorders.