CBR-470-2

• CAT Number: I045351
• CAS Number: 2416095-00-4
• Molecular Formula: C12H13Cl2NO6S2
• Molecular Weight: 402.27
• Purity: ≥95%
• Synonyms: 2-[[(3S,4R)-4-(3,4-dichlorophenyl)sulfonyl-1,1-dioxothiolan-3-yl]amino]acetic acid
• InChI: InChI=1S/C12H13Cl2NO6S2/c13-8-2-1-7(3-9(8)14)23(20,21)11-6-22(18,19)5-10(11)15-4-12(16)17/h1-3,10-11,15H,4-6H2,(H,16,17)/t10-,11-/m0/s1
• InChIKey: FNQDSYKGBCVHHI-QWRGUYRKSA-N
• SMILES: C1C(C(CS1(=O)=O)S(=O)(=O)C2=CC(=C(C=C2)Cl)Cl)NCC(=O)O

CBR-470-2 (Cat No.: I045351) is a potent and selective inhibitor of 6-phosphogluconate dehydrogenase (6PGD), an essential enzyme in the oxidative phase of the pentose phosphate pathway. By blocking 6PGD, CBR-470-2 disrupts NADPH production and ribose-5-phosphate synthesis, leading to impaired redox balance and nucleotide biosynthesis. This makes it a valuable tool for studying cancer metabolism, as many tumors rely on 6PGD for proliferation and survival. CBR-470-2 holds potential for therapeutic exploration targeting metabolic vulnerabilities in cancer and other proliferative disorders.

Reference

[1]. Bollong MJ, et, al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604.
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