CBR-470-1

• CAT Number: I045347
• CAS Number: 2416095-06-0
• Molecular Formula: C14H20ClNO4S2
• Molecular Weight: 365.89
• Purity: ≥95%

CBR-470-1 (Cat No.: I045347) is a potent and selective small-molecule inhibitor of 6-phosphogluconate dehydrogenase (6PGD), a key enzyme in the oxidative branch of the pentose phosphate pathway. By blocking 6PGD activity, CBR-470-1 disrupts cellular redox balance and nucleotide biosynthesis, making it a valuable tool in cancer metabolism research. It has shown potential in preclinical studies to impair tumor cell proliferation by targeting metabolic vulnerabilities. CBR-470-1 is instrumental for exploring therapeutic strategies that exploit altered metabolic pathways in cancer cells.

Reference

[1]. Bollong MJ, et, al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604.
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[2]. Zheng J, et, al. PGK1 inhibitor CBR-470-1 protects neuronal cells from MPP+. Aging (Albany NY). 2020 Jul 10;12(13):13388-13399.
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