CBP/p300-IN-8

For research use only. Not for therapeutic Use.

  • CAT Number: I044692
  • CAS Number: 2304416-91-7
  • Molecular Formula: C27H31N3O4
  • Molecular Weight: 461.55
  • Purity: ≥95%
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CBP/p300-IN-8(Cat No.:I044692)is a potent and selective small-molecule inhibitor targeting the histone acetyltransferase (HAT) activity of CBP (CREB-binding protein) and p300, two key transcriptional coactivators involved in chromatin remodeling and gene expression regulation. By blocking acetylation of histones and non-histone proteins, CBP/p300-IN-8 suppresses the transcription of oncogenes and other genes critical for cancer cell survival and proliferation. It has demonstrated strong antiproliferative effects in preclinical models of hematologic and solid tumors. CBP/p300-IN-8 is a valuable tool in epigenetic research and a promising candidate for targeted cancer therapy.


CAS Number 2304416-91-7
Synonyms

(1S,3S)-3-[(7S)-2-benzyl-6-methoxycarbonyl-7-methyl-8,9-dihydro-7H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid

Molecular Formula C27H31N3O4
Purity ≥95%
IUPAC Name (1S,3S)-3-[(7S)-2-benzyl-6-methoxycarbonyl-7-methyl-8,9-dihydro-7H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid
InChI InChI=1S/C27H31N3O4/c1-17-11-12-21-22(29(17)27(33)34-2)13-14-23-25(21)28-24(15-18-7-4-3-5-8-18)30(23)20-10-6-9-19(16-20)26(31)32/h3-5,7-8,13-14,17,19-20H,6,9-12,15-16H2,1-2H3,(H,31,32)/t17-,19-,20-/m0/s1
InChIKey ABNLUJMIBRFYRV-IHPCNDPISA-N
SMILES C[C@H]1CCC2=C(N1C(=O)OC)C=CC3=C2N=C(N3[C@H]4CCC[C@@H](C4)C(=O)O)CC5=CC=CC=C5
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