CBP/p300-IN-12

• CAT Number: I045399
• CAS Number: 2738688-57-6
• Molecular Formula: C33H29F4N5O6
• Molecular Weight: 667.61
• Purity: ≥95%

CBP/p300-IN-12 (Cat No.: I045399) is a potent and selective inhibitor of CBP (CREB-binding protein) and p300, two histone acetyltransferases involved in transcriptional regulation and epigenetic modification. By blocking the bromodomain activity of CBP/p300, this compound reduces acetylation of histone H3K27, leading to suppression of oncogene expression. It is widely used in cancer research, particularly for hematologic malignancies and solid tumors, where dysregulated CBP/p300 activity contributes to tumor progression, proliferation, and therapy resistance. CBP/p300-IN-12 serves as a valuable epigenetic probe in preclinical studies.

Reference

[1]. Anthony Mastracchio, et al. Discovery of a Potent and Selective Covalent p300/CBP Inhibitor. ACS Med Chem Lett. 2021 Apr 5;12(5):726-731.
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