CB2R PAM

• CAT Number: I026676
• CAS Number: 2244579-87-9
• Molecular Formula: C21H24BrFN2O2
• Molecular Weight: 435.33
• Purity: ≥95%
• Synonyms: N-[5-bromo-1-[(4-fluorophenyl)methyl]-4-methyl-2-oxopyridin-3-yl]cycloheptanecarboxamide
• InChI: InChI=1S/C21H24BrFN2O2/c1-14-18(22)13-25(12-15-8-10-17(23)11-9-15)21(27)19(14)24-20(26)16-6-4-2-3-5-7-16/h8-11,13,16H,2-7,12H2,1H3,(H,24,26)
• InChIKey: NSGDYZCDUPSTQT-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N(C=C1Br)CC2=CC=C(C=C2)F)NC(=O)C3CCCCCC3

CB2R PAM (Cat No.: I026676) is a positive allosteric modulator of the cannabinoid receptor type 2 (CB2R), a G protein–coupled receptor primarily expressed in immune cells and peripheral tissues. By binding to an allosteric site distinct from the orthosteric ligand-binding pocket, CB2R PAM enhances the receptor’s response to endogenous cannabinoids without directly activating it. This selective modulation allows for fine-tuning of CB2R-mediated signaling, potentially reducing side effects. CB2R PAM is used in research to explore therapeutic strategies for inflammation, pain, neuroprotection, and immune-related disorders.

Reference

[1]. Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62(1):276-287.
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