CAY10594

• CAT Number: R064367
• CAS Number: 1130067-34-3
• Molecular Formula: C26H28N4O2
• Molecular Weight: 428.53
• Purity: ≥95%
• Synonyms: N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide
• InChI: InChI=1S/C26H28N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-11,18H,12-17,19H2,(H,27,31)(H,28,32)
• InChIKey: FAIFAFUXFFWVNQ-UHFFFAOYSA-N
• SMILES: C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCNC(=O)C4=CC5=CC=CC=C5C=C4

CAY10594 (Cat No.: R064367) is a small-molecule inhibitor of TANK-binding kinase 1 (TBK1), a serine/threonine kinase that regulates innate immune signaling and interferon production. By blocking TBK1 activity, CAY10594 suppresses phosphorylation of IRF3 and downstream type I interferon responses. It is widely used as a research tool to study TBK1-dependent pathways in antiviral defense, inflammation, and cancer. Given TBK1’s involvement in autoimmunity and tumorigenesis, CAY10594 provides insights into therapeutic strategies aimed at modulating immune checkpoints and inflammatory signaling cascades.

Reference

[1]. Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness
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[2]. Lee SK, et al. A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Sci Rep. 2019 May 10;9(1):7242.
[Content Brief]