For research use only. Not for therapeutic Use.
CAY10502 (Cat No.: R024937) is a small-molecule NF-κB pathway inhibitor that suppresses inflammatory signaling by blocking IκB kinase (IKK) activity and preventing phosphorylation and degradation of IκBα. This inhibition keeps NF-κB sequestered in the cytoplasm, thereby reducing the transcription of pro-inflammatory genes such as TNF-α, IL-1β, and COX-2. CAY10502 has been used in studies of inflammation, immunity, and cancer, making it a valuable pharmacological probe for investigating NF-κB signaling, inflammatory disease mechanisms, and therapeutic target validation in drug discovery.
| CAS Number | 888320-29-4 |
| Synonyms | 1-[3-(4-decoxyphenoxy)-2-oxopropyl]-3-methoxycarbonylindole-5-carboxylic acid |
| Molecular Formula | C30H37NO7 |
| Purity | ≥95% |
| InChI | InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34) |
| InChIKey | NXDZVUAKVFVDSL-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCOC1=CC=C(C=C1)OCC(=O)CN2C=C(C3=C2C=CC(=C3)C(=O)O)C(=O)OC |
| Reference | [1]. Pohjala L L, et al. Interference by bovine serum albumin in PED6 based phospholipase A2 screening assays[J]. Die Pharmazie, 2012. [2]. Barnett JM, et al. Role of cytosolic phospholipase A(2) in retinal neovascularization. Invest Ophthalmol Vis Sci. 2010;51(2):1136-1142. [3]. Cui Y, et al. Exposure to extremely low-frequency electromagnetic fields inhibits T-type calcium channels via AA/LTE4 signaling pathway. Cell Calcium. 2014 Jan;55(1):48-58. |
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