CAY10415

  • CAT Number: I005690
  • CAS Number: 146062-49-9
  • Molecular Formula: C19H18N2O4S
  • Molecular Weight: 370.4
  • Purity: ≥95%
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CAY10415(CAT: I005690) is a novel peroxisome proliferator-activated receptor (PPAR)γ ligand. CAY10415 induced cell death and ROS generation in a PPARγ-independent manner. CAY10415 enhanced γ-radiation-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage in vitro. The combined CAY10415 / γ-radiation treatment triggered caspase-8 activation, and this initiator caspase played an important role in the combination-induced apoptosis. The combined treatment of CAY10415 and γ-radiation synergistically induced DNA damage and apoptosis, which was regulated by ROS.

Catalog Number I005690
CAS Number 146062-49-9
Synonyms

CAY10415; CAY-10415; CAY 10415.;5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione

Molecular Formula

C19H18N2O4S

Purity 95%
Solubility Soluble in DMSO, not in water
Storage Store at -20°C
InChI InChI=1S/C19H18N2O4S/c1-2-12-5-8-15(20-10-12)16(22)11-25-14-6-3-13(4-7-14)9-17-18(23)21-19(24)26-17/h3-8,10,17H,2,9,11H2,1H3,(H,21,23,24)
InChIKey IRNJSRAGRIZIHD-UHFFFAOYSA-N
SMILES CCc1ccc(nc1)C(=O)COc1ccc(cc1)CC1SC(=O)NC1=O

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