Catharanthine

• CAT Number: A000201
• CAS Number: 2468-21-5
• Molecular Formula: C₂₁H₂₄N₂O₂
• Molecular Weight: 336.43
• Purity: ≥95%
• Target: Neuronal Signaling
• Storage: 3 years -20C powder
• InChI: InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3
• InChIKey: CMKFQVZJOWHHDV-UHFFFAOYSA-N
• SMILES: CCC1=CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC

Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.Catharanthine evokes a concentration-dependent attenuation of carbachol responses in the rat ileum preparation, producing rightward curve displacements and decreases in maximal agonist responses. The mixture of serpentine, plus ajmalicine and catharanthine reveals a concentration-dependent inhibitory effect of acethylcholinesterase (AchE), with an IC50 at ca. 2.25 μg/mL.