(+)-Catechin (hydrate)

• CAT Number: R067355
• CAS Number: 225937-10-0
• Molecular Formula: C15H14O6 · XH2O
• Molecular Weight: 290.3
• Purity: ≥95%
• Synonyms: D-(+)-Catechin;Catechuic Acid;Cyanidol
• Target: COX
• Storage: 4°C
• InChI: InChI=1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1
• InChIKey: OFUMQWOJBVNKLR-NQQJLSKUSA-N
• SMILES: OC1=CC([C@@H](O2)[C@@H](O)CC3=C2C=C(O)C=C3O)=CC=C1O.O

Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-<wbr></wbr>tocopherol in certain in vitro assays of lipid peroxidation. Catechin inhibits the free radical-<wbr></wbr>induced oxidation of isolated LDL by AAPH. It has also been reported to act as an inhibitor of COX-<wbr></wbr>1 with an IC50 of about 80 µM. Catechin and other related procyanidin compounds have antitumor activity when tested in a two-<wbr></wbr>stage mouse epidermal carcinoma model employing topical application.

Reference

1.Zhao, J.,Wang, J.,Chen, Y., et al. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3/’-gallate as the most effective antioxi