For research use only. Not for therapeutic Use.
Casopitant Mesylate(CAT: R012848) is a potent, selective antagonist of the neurokinin-1 (NK1) receptor, developed for the prevention of chemotherapy-induced and postoperative nausea and vomiting. By blocking the binding of substance P to NK1 receptors in the central nervous system, Casopitant Mesylate suppresses emetic signaling pathways. Preclinical and clinical studies have highlighted its strong antiemetic efficacy and favorable pharmacological profile. Beyond emesis control, NK1 receptor antagonists like Casopitant are of research interest in pain modulation, depression, and stress-related disorders. Casopitant Mesylate is a valuable tool compound for studying neurokinin signaling and its therapeutic potential in neurological and gastrointestinal research.
| CAS Number | 414910-30-8 |
| Synonyms | (2R,4S)-4-(4-acetylpiperazin-1-yl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide;methanesulfonic acid |
| Molecular Formula | C31H39F7N4O5S |
| Purity | ≥95% |
| InChI | InChI=1S/C30H35F7N4O2.CH4O3S/c1-18-13-24(31)5-6-26(18)27-17-25(40-11-9-39(10-12-40)20(3)42)7-8-41(27)28(43)38(4)19(2)21-14-22(29(32,33)34)16-23(15-21)30(35,36)37;1-5(2,3)4/h5-6,13-16,19,25,27H,7-12,17H2,1-4H3;1H3,(H,2,3,4)/t19-,25+,27-;/m1./s1 |
| InChIKey | YRFKYVWDPCOSTE-REWBLLDVSA-N |
| SMILES | CC1=C(C=CC(=C1)F)C2CC(CCN2C(=O)N(C)C(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C(=O)C.CS(=O)(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
