Casein Kinase 2 Substrate Peptide

• CAT Number: I042448
• CAS Number: 132176-35-3
• Molecular Formula: C45H73N19O24
• Molecular Weight: 1264.17
• Purity: ≥95%
• Synonyms: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-carboxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-carboxypropanoyl]amino]butanedioic acid
• InChI: InChI=1S/C45H73N19O24/c46-17(4-1-7-53-43(47)48)33(78)56-18(5-2-8-54-44(49)50)34(79)57-19(6-3-9-55-45(51)52)35(80)58-20(10-27(66)67)36(81)59-21(11-28(68)69)37(82)61-24(14-31(74)75)40(85)64-26(16-65)41(86)62-22(12-29(70)71)38(83)60-23(13-30(72)73)39(84)63-25(42(87)88)15-32(76)77/h17-26,65H,1-16,46H2,(H,56,78)(H,57,79)(H,58,80)(H,59,81)(H,60,83)(H,61,82)(H,62,86)(H,63,84)(H,64,85)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,87,88)(H4,47,48,53)(H4,49,50,54)(H4,51,52,55)/t17-,18-,19-,20-,21-,22-,23-,24-,25-,26-/m0/s1
• InChIKey: MROOTBWJKIXJEW-VPHKHLIQSA-N
• SMILES: C(CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)O)C(=O)O)N)CN=C(N)N

Casein Kinase 2 (CK2) Substrate Peptide (Cat No.: I042448) is a synthetic peptide sequence specifically designed to be phosphorylated by CK2, a serine/threonine protein kinase involved in cell growth, survival, and signal transduction. This peptide serves as a valuable tool in kinase activity assays, substrate specificity studies, and high-throughput inhibitor screening. By mimicking natural CK2 phosphorylation sites, it enables precise monitoring of enzymatic activity in vitro. CK2 substrate peptides are essential for dissecting signaling pathways and developing targeted kinase inhibitors.

Reference

[1]. Gratz A, et al. A CE-based assay for human protein kinase CK2 activity measurement and inhibitor screening. Electrophoresis. 2010 Jan;31(4):634-40.
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