Cariprazine - CAS 839712-12-8

Cariprazine(CAT: I005031) is a psychotropic agent that acts as a partial agonist at dopamine D2 and D3 receptors, as well as a partial agonist at serotonin 5-HT1A receptors. It is primarily used in the treatment of schizophrenia and bipolar disorder. Cariprazine’s pharmacological action involves modulating the activity of dopamine and serotonin receptors in the brain, which helps regulate neurotransmitter imbalances associated with these psychiatric conditions. By acting as a partial agonist, it provides a more balanced and selective effect compared to traditional antipsychotic medications. Cariprazine has demonstrated efficacy in reducing symptoms of psychosis and mood disturbances, offering a valuable treatment option for patients with these disorders.

Catalog Number: I005031

CAS Number: 839712-12-8

PubChem Substance ID:355039414

Molecular Formula: C21H32Cl2N4O

Molecular Weight:427.41

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsRGH-188; RGH188; RGH 188; MP-214; MP 214; MP214; Cariprazine. trade name Vraylar

Property

Molecular Formula: C21H32Cl2N4O
Molecular Weight427.41
Target:Dopamine Receptor
Solubility10 mM in DMSO
Purity≥95%
StorageStore at -20°C
IC500.5 and 0.09 nM (Ki for D2 and D3 receptor respectively); 2.6 and 180 nM (Ki for 5-HT1A and 5-HT2A receptor respectively)

Computed Descriptor

InChI1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-
InChIKeyKPWSJANDNDDRMB-QAQDUYKDSA-N
SMILESCN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl