Carcainium chloride

• CAT Number: R024066
• CAS Number: 1042-42-8
• Molecular Formula: C18H22ClN3O2
• Molecular Weight: 347.84
• Purity: ≥95%
• Synonyms: bis(2-anilino-2-oxoethyl)-dimethylazanium;chloride
• InChI: InChI=1S/C18H21N3O2.ClH/c1-21(2,13-17(22)19-15-9-5-3-6-10-15)14-18(23)20-16-11-7-4-8-12-16;/h3-12H,13-14H2,1-2H3,(H-,19,20,22,23);1H
• InChIKey: YGCONRRHHMKQRL-UHFFFAOYSA-N
• SMILES: C[N+](C)(CC(=O)NC1=CC=CC=C1)CC(=O)NC2=CC=CC=C2.[Cl-]

Carcainium chloride (CAT: R024066) is a quaternary ammonium derivative of lidocaine known for its membrane-stabilizing and local anesthetic-like properties. Unlike lidocaine, QX-572 is permanently charged, restricting its permeability across lipid membranes, which allows it to act selectively on extracellular sodium channels. Studies have demonstrated its antitussive (cough-suppressing) effects, likely mediated through inhibition of vagal afferent nerve activity and modulation of airway sensory pathways. Carcainium chloride is widely used in research exploring neuronal excitability, ion channel pharmacology, and respiratory reflex regulation, providing valuable insights into structure–activity relationships of local anesthetic analogs.