For research use only. Not for therapeutic Use.
Carboxylesterase-IN-3（Cat No.:I044083）is a potent and selective inhibitor of carboxylesterases (CES), key enzymes involved in the hydrolysis of ester- and amide-containing xenobiotics and endogenous compounds. By blocking CES activity, this compound modulates drug metabolism, prodrug activation, and lipid processing, making it valuable in pharmacokinetic studies, toxicity profiling, and drug–drug interaction assessments. Carboxylesterase-IN-3 is especially useful in evaluating liver and intestinal CES isoforms (e.g., CES1, CES2) to better understand their roles in drug bioavailability and clearance. It is a critical tool in ADME research and in the design of metabolically stable therapeutics.
| CAS Number | 2764748-92-5 |
| Synonyms | 6-(3,4-dichlorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one |
| Molecular Formula | C11H6Cl2N4OS |
| Purity | ≥95% |
| IUPAC Name | 6-(3,4-dichlorophenyl)sulfanyl-2H-[1,2,4]triazolo[4,3-b]pyridazin-3-one |
| InChI | InChI=1S/C11H6Cl2N4OS/c12-7-2-1-6(5-8(7)13)19-10-4-3-9-14-15-11(18)17(9)16-10/h1-5H,(H,15,18) |
| InChIKey | DYBIDXYUMDMCON-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1SC2=NN3C(=NNC3=O)C=C2)Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
