For research use only. Not for therapeutic Use.
Carboxyamidotriazole Orotate (CAT: M133503) is an orally active calcium influx inhibitor with antitumor and antiangiogenic properties. It acts by blocking non–voltage-gated calcium channels, thereby disrupting calcium-dependent signaling pathways essential for tumor growth, survival, and angiogenesis. Formulated as the orotate salt to improve solubility and bioavailability, CTO has shown promise in preclinical and clinical studies for various solid tumors, including glioblastoma, ovarian cancer, and renal cell carcinoma. By targeting both tumor cell proliferation and neovascularization, Carboxyamidotriazole Orotate represents a potential therapeutic strategy for cancer research, offering dual action against malignant progression and the supportive tumor microenvironment.
| CAS Number | 187739-60-2 |
| Synonyms | 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]triazole-4-carboxamide;2,4-dioxo-1H-pyrimidine-6-carboxylic acid |
| Molecular Formula | C22H16Cl3N7O6 |
| Purity | ≥95% |
| IUPAC Name | 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]triazole-4-carboxamide;2,4-dioxo-1H-pyrimidine-6-carboxylic acid |
| InChI | InChI=1S/C17H12Cl3N5O2.C5H4N2O4/c18-10-3-1-9(2-4-10)15(26)13-11(19)5-8(6-12(13)20)7-25-16(21)14(17(22)27)23-24-25;8-3-1-2(4(9)10)6-5(11)7-3/h1-6H,7,21H2,(H2,22,27);1H,(H,9,10)(H2,6,7,8,11) |
| InChIKey | MNWOBDDXRRBONM-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C(=O)C2=C(C=C(C=C2Cl)CN3C(=C(N=N3)C(=O)N)N)Cl)Cl.C1=C(NC(=O)NC1=O)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
